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DSG-PEG 2000 is a PEG-modified lipid that can be used with cationic lipids such as D-Lin-MC3-DMA (No A8791) to prepare cationic nanoparticles (LNP) capable of encapsulating and delivering siRNA mRNA DNA or small molecules into the cytoplasm
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DSPE-PEG2000-Mal ammonium contains DSPE phospholipid and maleimide, designed for preparing nanostructured lipid carriers. It is known to extend blood circulation time and increase stability for encapsulated agents. Immune liposomes constructed with this product can be utilized for brain drug delivery.
Contains DSPE phospholipid and maleimide
Prepares nanostructured lipid carriers
Extends blood circulation time
Increases stability for encapsulated agents
Can be used for brain drug delivery with immune liposomes
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Lipid A is one of the components of the lipopolysaccharide molecule of Gram-negative bacteria. It is responsible for the toxicity of these bacteria. It has two glucosamine units with a (1--6) glycosidic linkage.
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DMG-PEG2000-Biotin is a synthetic amphiphilic molecule composed of dimyristoyl glycerol (DMG) polyethylene glycol (PEG2000) and biotin functionalities It is commonly employed in biomedical research for surface modification of lipid-based delivery platforms such as lipid nanoparticles (LNPs) and liposomes The PEG moiety enhances colloidal stability prolongs circulation time and reduces rapid clearance in vivo The biotin termination facilitates conjugation to streptavidin-tagged biomolecules exploiting the highly specific biotin-streptavidin interaction Thus DMG-PEG2000-Biotin is valuable for drug-delivery optimization targeted therapeutic approaches and in vitro diagnostic assay development
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Differential Ion Mobility System Suitability Synthetic Standard Mixture. Mixture contains 1mg/ml of each lipid below (0.25mg/ml PI), 0.5ml per vial in chloroform: methanol (1:1). We recommend purchasing Bovine Heart Extract as an accompanying product.
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A triacylglycerol; been used to characterize the functionality of R. oryzae lipase for regiodistribution analysis of fats containing medium- and short-chain fatty acids
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An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity
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PEG2000-C-DMG is a pegylated lipid used in the preparation of Onpattro, an investigational RNAi therapeutic agent. Onpattro is hepatically directed and reduces the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA.
Pegylated lipid
Used in the preparation of Onpattro
Onpattro is an investigational RNAi therapeutic agent
Onpattro reduces production of mutant and wild-type transthyretin
Targets 3′ untranslated region of transthyretin mRNA
Suitable for research use only
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